SCHEMBL9727243

SCHEMBL9727243

O=C(NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1)c1cc2ccccc2o1

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 1/20 0.69
SIGMAR1 Q99720 4/20 0.62
MAOB P27338 1/20 0.59
RAB9A P51151 2/20 0.57
UTS2R Q9UKP6 1/20 0.56
ACHE P22303 3/20 0.54
BCHE P06276 2/20 0.54
BACE1 P56817 1/20 0.54
NPC1 O15118 1/20 0.53
TP53 P04637 1/20 0.53
MAPK1 P28482 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
ALOX5 P09917 1/20 0.53
MAOA P21397 1/20 0.53
KCNH2 Q12809 2/20 0.52
MCHR1 Q99705 2/20 0.52
DRD3 P35462 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9727131 0.88 MAOB (0.74) DRD4MAOBRAB9AUTS2RACHE
SCHEMBL9727117 0.87 DRD4 (0.67) DRD4SIGMAR1MAOBRAB9AUTS2R
SCHEMBL9727166 0.87 ACHE (0.66) DRD4SIGMAR1MAOBRAB9AUTS2R
SCHEMBL9852220 0.86 DRD4 (0.64) DRD4SIGMAR1MAOBRAB9AACHE
SCHEMBL9852126 0.84 MCHR1 (0.60) DRD4SIGMAR1UTS2RACHEKCNH2
SCHEMBL16927793 0.84 MAOB (0.63) DRD4SIGMAR1MAOBRAB9AUTS2R
SCHEMBL9727169 0.83 MCHR1 (0.59) DRD4SIGMAR1UTS2RACHEKCNH2
SCHEMBL9852059 0.83 UTS2R (0.64) DRD4MAOBRAB9AUTS2RACHE
SCHEMBL9727091 0.83 DRD4 (0.70) DRD4SIGMAR1MAOBRAB9AUTS2R
SCHEMBL9852055 0.82 MCHR1 (0.66) DRD4MAOBRAB9AUTS2RACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5098915-A Antiarrhythmia agents G. D. SEARLE & CO. (US) 1992-03-24 US claimed
EP-0416581-A1 Substituted N-benzylpiperidine amides G.D. Searle & Co. (US) 1991-03-13 EP claimed