Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.62 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.55 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727131 | 0.92 | MAOB (0.74) | ACHEMAOBRAB9AUTS2RMCHR1 | |
| SCHEMBL9727117 | 0.91 | DRD4 (0.67) | ACHEMAOBRAB9AUTS2RSIGMAR1 | |
| SCHEMBL16927793 | 0.88 | MAOB (0.63) | ACHEMAOBRAB9AUTS2RSIGMAR1 | |
| SCHEMBL650728 | 0.88 | ACHE (0.76) | ACHEMAOBSIGMAR1MCHR1KCNH2 | |
| SCHEMBL9727091 | 0.88 | DRD4 (0.70) | ACHEMAOBRAB9AUTS2RSIGMAR1 | |
| SCHEMBL9852059 | 0.88 | UTS2R (0.64) | ACHEMAOBRAB9AUTS2RNPC1 | |
| SCHEMBL9852055 | 0.87 | MCHR1 (0.66) | ACHEMAOBRAB9AUTS2RNPC1 | |
| SCHEMBL9727243 | 0.87 | DRD4 (0.69) | ACHEMAOBRAB9ABCHEUTS2R | |
| SCHEMBL9482251 | 0.85 | MAOB (0.57) | ACHEMAOBRAB9AUTS2RNPC1 | |
| SCHEMBL9727140 | 0.84 | UTS2R (0.73) | ACHEMAOBRAB9AUTS2RMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |