SCHEMBL9727642

SCHEMBL9727642

Cc1cccc(SC#N)c1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
TRPA1 O75762 2/20 0.45
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 1/20 0.38
LDHA P00338 2/20 0.38
LDHB P07195 2/20 0.38
ATM Q13315 2/20 0.35
POLB P06746 1/20 0.35
TSHR P16473 1/20 0.34
KMT2A Q03164 3/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
AR P10275 1/20 0.33
USP2 O75604 1/20 0.31
USP8 P40818 1/20 0.31
USP5 P45974 1/20 0.31
USP4 Q13107 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7936881 0.79 TRPA1 (0.38) ALDH1A1TRPA1ATMPOLBTSHR
SCHEMBL9078886 0.79 ALDH1A1 (0.46) ALDH1A1TRPA1KDM4EHPGDHSD17B10
SCHEMBL231786 0.79 TSHR (0.44) ALDH1A1KDM4EHSD17B10POLBTSHR
SCHEMBL6285174 0.76 ALDH1A1 (0.62) ALDH1A1TRPA1GABRA1GABRB2KDM4E
SCHEMBL31684003 0.76 ALDH1A1 (0.62) ALDH1A1TRPA1GABRA1GABRB2KDM4E
SCHEMBL15083368 0.76 ALDH1A1 (0.62) ALDH1A1TRPA1GABRA1GABRB2KDM4E
SCHEMBL21495996 0.76 ALDH1A1 (0.40) ALDH1A1POLBTSHRCYP3A4AR
SCHEMBL27491094 0.75 ALDH1A1 (0.78) ALDH1A1TRPA1GABRA1GABRB2KDM4E
SCHEMBL28278985 0.74 ALDH1A1 (0.59) ALDH1A1TRPA1GABRA1GABRB2KDM4E
Cyanate SCHEMBL27968920 0.73 ALDH1A1 (0.74) ALDH1A1TRPA1GABRA1GABRB2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4145006-A None JP disclosed
JP-H04145006-A INSECT-PROOFING AGENT COMPOSED MAINLY OF AROMATIC THIOCYANIC ACID COMPOUND AND SUITABLE FOR CORRUGATED FIBERBOARD, PAPER AND PAPER PRODUCT RENGO CO LTD 1992-05-19 JP disclosed