Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502112 | 0.87 | DRD2 (0.45) | DRD4 | |
| SCHEMBL9727764 | 0.78 | IGF1R (0.35) | TBXA2RHRH4HRH3 | |
| SCHEMBL5542006 | 0.78 | SHBG (0.48) | HRH4HRH3MEN1MAPTKMT2A | |
| SCHEMBL9727481 | 0.77 | HRH3 (0.42) | TBXA2RHRH4HRH3 | |
| SCHEMBL5548100 | 0.75 | SHBG (0.43) | HRH4HRH3MEN1MAPTKMT2A | |
| SCHEMBL7798235 | 0.74 | FFAR4 (0.52) | DPP4ESR1ESR2 | |
| SCHEMBL5536727 | 0.74 | GRM2 (0.44) | HRH4HRH3DRD4 | |
| SCHEMBL5536594 | 0.74 | MEN1 (0.50) | HRH4HRH3MEN1MAPTKMT2A | |
| SCHEMBL5537748 | 0.73 | GRM2 (0.46) | HRH4HRH3DRD4 | |
| SCHEMBL7290115 | 0.73 | HRH3 (0.54) | TBXA2RHRH4HRH3MAPTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |