Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501181 | 0.89 | HRH3 (0.43) | HRH3ADRA2AADRA2BADRA2CMAOB | |
| SCHEMBL9727775 | 0.77 | TBXA2R (0.45) | HRH3TBXA2RHRH4 | |
| SCHEMBL14435045 | 0.70 | ALOX15 (0.44) | — | |
| SCHEMBL5505186 | 0.70 | HRH3 (0.55) | HRH3 | |
| SCHEMBL9727516 | 0.69 | NR1I2 (0.33) | HRH3HRH4MAOA | |
| SCHEMBL9727677 | 0.67 | PTGDR2 (0.38) | MAOBMAOA | |
| SCHEMBL3453122 | 0.67 | CA12 (0.53) | ADRA2AADRA2BADRA2CHPGDMAOB | |
| SCHEMBL5502112 | 0.66 | DRD2 (0.45) | — | |
| SCHEMBL9727764 | 0.65 | IGF1R (0.35) | HRH3TBXA2RHRH4 | |
| SCHEMBL10509092 | 0.65 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CHPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |