Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.84 |
| ▸ | USP2 | O75604 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.84 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.84 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.84 |
| ▸ | GMNN | O75496 | 1/20 | 0.82 |
| ▸ | APEX1 | P27695 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirenzepine SCHEMBL29793172 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL41705 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30553045 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL9254860 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| SCHEMBL9728271 | 0.91 | CHRM2 (0.78) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL2732205 | 0.91 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL348603 | 0.91 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL41704 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL15300969 | 0.91 | LMNA (0.98) | LMNACHRM2CHRM1USP2ALDH1A1 | |
| Pirenzepine SCHEMBL30548470 | 0.91 | LMNA (1.00) | LMNACHRM2CHRM1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175158-A | CONDENSED DIAZEPINONES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | DR. KARL THOMAE, GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0312895-A2 | Condensed diazepinones, process for their preparation and medicament containing them | Dr. Karl Thomae GmbH (DE) | 1989-04-26 | — | — | EP | disclosed |