Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432630 | 0.80 | ALDH1A1 (0.63) | KDM4ESMN1; SMN2PIK3CAPI4KAPI4KB | |
| SCHEMBL9727832 | 0.80 | CYP2A6 (0.49) | SMN1; SMN2ALDH1A1CYP2A6CYP3A4CYP2D6 | |
| SCHEMBL9833618 | 0.80 | SMN1; SMN2 (0.51) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIP5K1C | |
| SCHEMBL6545502 | 0.79 | ALDH1A1 (0.72) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIP5K1C | |
| SCHEMBL1850222 | 0.76 | ADORA2A (0.54) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIP5K1C | |
| SCHEMBL13930450 | 0.75 | PIK3CA (0.52) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL9728291 | 0.73 | CYP2A6 (0.42) | KDM4ESMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL27680210 | 0.72 | ADORA3 (0.48) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIP5K1C | |
| SCHEMBL19839753 | 0.72 | ALDH1A1 (0.51) | TGFBR1KDM4ESMN1; SMN2PIK3CDPIP5K1C | |
| SCHEMBL13910994 | 0.71 | CYP2A6 (0.70) | KDM4ESMN1; SMN2ALDH1A1MAPTCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128340-A | Thiazole derivatives | AKZO N.V. (NL) | 1992-07-07 | — | — | US | disclosed |
| EP-0372125-A1 | Oxazole and thiazole derivatives | AKZO N.V. (NL) | 1990-06-13 | — | — | EP | disclosed |
| EP-0368384-A1 | Thiazole derivatives | AKZO N.V. (NL) | 1990-05-16 | — | — | EP | disclosed |