SCHEMBL9727832

SCHEMBL9727832

Cc1nc(-c2cccnc2)c(Cl)s1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 11/20 0.49
CYP3A4 P08684 6/20 0.45
NPY5R Q15761 4/20 0.45
ALDH1A1 P00352 3/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2E1 P05181 4/20 0.45
CYP2C9 P11712 4/20 0.45
CYP2B6 P20813 4/20 0.45
CYP2C19 P33261 4/20 0.44
LMNA P02545 1/20 0.44
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP2D6 P10635 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8472476 0.83 CYP2A6 (0.51) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2
SCHEMBL9727980 0.80 TGFBR1 (0.51) CYP2A6CYP3A4ALDH1A1CYP1A2CYP2E1
SCHEMBL22650223 0.80 CYP2A6 (0.49) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2
SCHEMBL31469332 0.80 CYP2A6 (0.49) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2
SCHEMBL13494032 0.75 GPR35 (0.54) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2
SCHEMBL31469304 0.74 CYP2A6 (0.40) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2
SCHEMBL14564368 0.73 RORB (0.42) ALDH1A1LMNAHPGDL3MBTL1
SCHEMBL12158050 0.73 MAPT (0.59) ALDH1A1LMNANPC1HPGDSMN1; SMN2
SCHEMBL9728291 0.73 CYP2A6 (0.42) CYP2A6CYP3A4ALDH1A1CYP1A2CYP2E1
SCHEMBL13910994 0.71 CYP2A6 (0.70) CYP2A6CYP3A4NPY5RALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5128340-A Thiazole derivatives AKZO N.V. (NL) 1992-07-07 US disclosed
EP-0372125-A1 Oxazole and thiazole derivatives AKZO N.V. (NL) 1990-06-13 EP disclosed
EP-0368384-A1 Thiazole derivatives AKZO N.V. (NL) 1990-05-16 EP disclosed