Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728779 | 0.91 | MAPK1 (0.43) | MAPTL3MBTL1PKMALDH1A1LMNA | |
| SCHEMBL9193373 | 0.91 | PKM (0.51) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9728757 | 0.90 | PKM (0.41) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9728356 | 0.85 | MAPT (0.49) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9728169 | 0.85 | MAPT (0.41) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9198733 | 0.84 | POLB (0.40) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9196221 | 0.81 | MAPT (0.46) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9728699 | 0.75 | KCNQ2 (0.41) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9196029 | 0.75 | L3MBTL1 (0.51) | MAPTL3MBTL1PKMALDH1A1KMT2A | |
| SCHEMBL9196693 | 0.71 | ADRB2 (0.43) | MAPTPKMALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |