Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728112 | 0.83 | RAD52 (0.43) | RAD52 | |
| SCHEMBL9728716 | 0.81 | CHRM2 (0.41) | ADRA2AADRA2BADRA2C | |
| SCHEMBL9728829 | 0.79 | DRD4 (0.38) | DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL9728485 | 0.79 | DRD2 (0.43) | DRD2DRD3ALDH1A1 | |
| SCHEMBL9728399 | 0.78 | CHRM1 (0.35) | — | |
| SCHEMBL9728317 | 0.76 | CHRM1 (0.55) | — | |
| SCHEMBL3260581 | 0.75 | MAPT (0.42) | MAPTLMNAADRA2ADRD2ADRA2B | |
| SCHEMBL25426350 | 0.66 | CHEK1 (0.38) | ADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL10767827 | 0.65 | OPRD1 (0.44) | LMNAADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL9729003 | 0.64 | CHRM2 (0.40) | ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128340-A | Thiazole derivatives | AKZO N.V. (NL) | 1992-07-07 | — | — | US | disclosed |
| EP-0372125-A1 | Oxazole and thiazole derivatives | AKZO N.V. (NL) | 1990-06-13 | — | — | EP | disclosed |
| EP-0368384-A1 | Thiazole derivatives | AKZO N.V. (NL) | 1990-05-16 | — | — | EP | disclosed |