Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728485 | 0.90 | DRD2 (0.43) | DRD4DRD2DRD3ALDH1A1SIGMAR1 | |
| SCHEMBL9728716 | 0.82 | CHRM2 (0.41) | SIGMAR1 | |
| SCHEMBL9728112 | 0.82 | RAD52 (0.43) | — | |
| SCHEMBL9729439 | 0.80 | MAOA (0.39) | KDM4EALDH1A1 | |
| SCHEMBL10699109 | 0.79 | LTA4H (0.41) | DRD4LSS | |
| SCHEMBL9728521 | 0.79 | MAPT (0.41) | DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL9728399 | 0.77 | CHRM1 (0.35) | — | |
| SCHEMBL9728317 | 0.75 | CHRM1 (0.55) | — | |
| SCHEMBL9728494 | 0.68 | CHRM2 (0.45) | SIGMAR1 | |
| SCHEMBL9728927 | 0.68 | CHRM2 (0.43) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128340-A | Thiazole derivatives | AKZO N.V. (NL) | 1992-07-07 | — | — | US | disclosed |
| EP-0372125-A1 | Oxazole and thiazole derivatives | AKZO N.V. (NL) | 1990-06-13 | — | — | EP | disclosed |
| EP-0368384-A1 | Thiazole derivatives | AKZO N.V. (NL) | 1990-05-16 | — | — | EP | disclosed |