Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | PKM | P14618 | 5/20 | 0.59 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728432 | 0.92 | NPC1 (0.56) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL9728922 | 0.87 | NPC1 (0.70) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL24169384 | 0.84 | ESR1 (0.56) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL9728665 | 0.79 | NPC1 (0.57) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL11700747 | 0.76 | NPC1 (0.69) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL9728941 | 0.75 | NPC1 (0.67) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL9728547 | 0.75 | RAB9A (0.58) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL11706816 | 0.74 | NPC1 (1.00) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL30387611 | 0.74 | NPC1 (0.70) | NPC1RAB9APKMKLF5OPRK1 | |
| SCHEMBL9729182 | 0.74 | NPC1 (0.70) | NPC1RAB9APKMKLF5OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | disclosed |