Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728922 | 0.86 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9728941 | 0.86 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9728432 | 0.84 | NPC1 (0.56) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL8558926 | 0.84 | RAB9A (0.81) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9729182 | 0.79 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL30387611 | 0.79 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL9729002 | 0.79 | ALPL (0.51) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL9728591 | 0.79 | NPC1 (0.59) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL9728959 | 0.78 | RAB9A (0.72) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7456210 | 0.77 | LMNA (0.65) | NPC1RAB9AMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | claimed |
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | disclosed |