Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.70 |
| ▸ | CCKBR | P32239 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 5/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.52 |
| ▸ | SCD | O00767 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30387611 | 1.00 | NPC1 (0.70) | NPC1RAB9ACCKBRKMT2ASMN1; SMN2 | |
| SCHEMBL9728941 | 0.89 | NPC1 (0.67) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9728922 | 0.87 | NPC1 (0.70) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9728959 | 0.84 | RAB9A (0.72) | NPC1RAB9AKMT2ASMN1; SMN2MAPT | |
| SCHEMBL11206434 | 0.82 | NPC1 (1.00) | NPC1RAB9AKMT2ASMN1; SMN2MAPT | |
| SCHEMBL9728665 | 0.79 | NPC1 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13977066 | 0.78 | KMT2A (0.69) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30387562 | 0.78 | KMT2A (0.69) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7456210 | 0.77 | LMNA (0.65) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9729002 | 0.76 | ALPL (0.51) | NPC1RAB9AKMT2ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | claimed |
| US-20230201206-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | THE PENN STATE RESEARCH FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | THE PENN STATE RESEARCH FOUNDATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | THE PENN STATE RESEARCH FOUNDATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-20210401843-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | THE PENN STATE RESEARCH FOUNDATION | 2021-12-30 | — | — | US | disclosed |
| US-9221840-B2 | Treating protein folding disorders with small molecule CFTR correctors | DISCOVERYBIOMED INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221840-B2 | Treating protein folding disorders with small molecule CFTR correctors | DISCOVERYBIOMED INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | THE UAB RESEARCH FOUNDATION (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | THE UAB RESEARCH FOUNDATION (US) | 2014-03-13 | — | — | US | disclosed |
| WO-2012158913-A2 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | DISCOVERYBIOMED INC. (US) | 2012-11-22 | — | — | WO | disclosed |
| US-5084457-A | Cognition activators and nervous system disorders | AMERICAN CYANAMID COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | CFTR, CLCN2, SLC47A1 | NPC1 48/4885RAB9A 337/4885CCKBR 3513/4885 |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | CLPP, SPOUT1, CASP3 | NPC1 1243/4885RAB9A 2358/4885CCKBR 1855/4885 |
| US-20210401843-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | CLPP, SPOUT1, CASP3 | NPC1 1243/4885RAB9A 2358/4885CCKBR 1855/4885 |
| US-20230201206-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | CLPP, SPOUT1, CASP3 | NPC1 1243/4885RAB9A 2358/4885CCKBR 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.