Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.53 |
| ▸ | PIM1 | P11309 | 12/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877170 | 0.92 | NTRK1 (0.64) | NTRK1PIM1GAAL3MBTL1LMNA | |
| SCHEMBL9877172 | 0.92 | NTRK1 (0.64) | NTRK1PIM1GAAL3MBTL1LMNA | |
| SCHEMBL9878320 | 0.82 | KDM4E (0.48) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL9728647 | 0.82 | KDM4E (0.48) | NTRK1PIM1ACVR1CHEK1CDK2 | |
| SCHEMBL9877259 | 0.79 | NTRK1 (0.43) | NTRK1PIM1GAAACVR1CHEK1 | |
| SCHEMBL9877954 | 0.76 | MAPT (0.53) | NTRK1PIM1GAAL3MBTL1CHEK1 | |
| SCHEMBL9728968 | 0.70 | CLK4 (0.61) | NTRK1PIM1GAAHTTKDM4E | |
| SCHEMBL9728973 | 0.70 | CLK4 (0.61) | NTRK1PIM1GAAHTTKDM4E | |
| SCHEMBL29283640 | 0.68 | NTRK1 (0.65) | NTRK1PIM1GAAACVR1CHEK1 | |
| SCHEMBL9877202 | 0.67 | TLR8 (0.67) | PIM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | claimed |
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5059691-A | Anxiolytic agents; hypotensive agents; nervous system disorders; cognition activators | AMERICAN CYANAMID COMPANY (US) | 1991-10-22 | — | — | US | disclosed |