Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 16/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728907 | 0.79 | SMPD3 (0.48) | HSD11B1 | |
| SCHEMBL9729081 | 0.79 | SMPD3 (0.48) | HSD11B1 | |
| SCHEMBL310126 | 0.77 | PDE2A (0.59) | PDE2AHSD11B1PDE10APDE3A | |
| SCHEMBL21326698 | 0.74 | PDE2A (0.53) | PDE2AHSD11B1PDE10APDE3A | |
| SCHEMBL19045790 | 0.72 | PDE2A (0.57) | PDE2AHSD11B1PDE10APDE3A | |
| SCHEMBL17781274 | 0.70 | KDM4E (0.57) | PDE2APDE10APDE3ARECQL | |
| SCHEMBL9877202 | 0.67 | TLR8 (0.67) | PDE3A | |
| SCHEMBL9728825 | 0.67 | TLR8 (0.67) | PDE3A | |
| SCHEMBL9728973 | 0.66 | CLK4 (0.61) | — | |
| SCHEMBL9728968 | 0.66 | CLK4 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169850-A | Neurotropic or hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-12-08 | — | — | US | claimed |