Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NAAA | Q02083 | 4/20 | 0.57 |
| ▸ | FAAH | O00519 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9576428 | 0.96 | NPC1 (0.59) | NPC1RAB9AMAPK1SMN1; SMN2TP53 | |
| SCHEMBL10839399 | 0.87 | NPC1 (0.62) | NPC1RAB9AMAPK1SMN1; SMN2TP53 | |
| SCHEMBL6439273 | 0.81 | LMNA (0.58) | SMN1; SMN2MAPTLMNANAAAFAAH | |
| SCHEMBL4404820 | 0.81 | NPC1 (0.58) | NPC1RAB9AMAPK1SMN1; SMN2TP53 | |
| SCHEMBL24044661 | 0.81 | NAAA (0.61) | NPC1RAB9AMAPK1SMN1; SMN2TP53 | |
| SCHEMBL5180649 | 0.81 | LMNA (0.84) | RAB9AMAPTTSHRLMNANAAA | |
| SCHEMBL5182683 | 0.79 | LMNA (0.81) | MAPTTSHRLMNANAAAFAAH | |
| SCHEMBL5182541 | 0.77 | LMNA (1.00) | RAB9AMAPTTSHRLMNAMEN1 | |
| SCHEMBL8599293 | 0.76 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2NAAAMEN1 | |
| SCHEMBL7132798 | 0.76 | LMNA (0.74) | SMN1; SMN2MAPTLMNANAAAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102896-A | 1-ACYL-2-PYRROLIDINONES AS ENHANCERS OF LEARNING AND MEMORY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1992-04-07 | — | — | US | disclosed |
| EP-0412058-A1 | 1-acyl-2-pyrrolidinones as enhancers of learning and memory and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-02-06 | — | — | EP | disclosed |