Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10839399 | 0.89 | NPC1 (0.62) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL2722040 | 0.84 | LMNA (0.46) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL12735068 | 0.84 | NAAA (0.52) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL6535800 | 0.83 | ALDH1A1 (0.64) | TDP1MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL9729678 | 0.81 | NPC1 (0.60) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL20196333 | 0.80 | POLB (0.45) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL4400997 | 0.80 | KCNJ1 (0.51) | MAPTMAPK1SMN1; SMN2TSHRPOLB | |
| SCHEMBL9576428 | 0.80 | NPC1 (0.59) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL14297019 | 0.78 | POLB (0.49) | NPC1TDP1MAPTMAPK1RAB9A | |
| SCHEMBL7269558 | 0.78 | NAAA (0.81) | FKBP1ANAAAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318806-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | claimed |
| EP-1318806-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-18 | — | — | EP | claimed |
| WO-2002024197-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-28 | — | — | WO | claimed |
| WO-2012059873-A2 | ANTI-DIABETIC COMPOUNDS | COVX TECHNOLOGIES IRELAND, LTD. (IE) | 2012-05-10 | — | — | WO | disclosed |
| US-20110087010-A1 | ANTI-ANGIOGENIC COMPOUNDS | COVX TECHNOLOGIES IRELAND LIMITED | 2011-04-14 | — | — | US | disclosed |
| US-20080152660-A1 | Anti-Angiogenic Compounds | COVX TECHNOLOGIES IRELAND LIMITED (IE) | 2008-06-26 | — | — | US | disclosed |
| EP-1318806-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1318806-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024197-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110087010-A1 | ANTI-ANGIOGENIC COMPOUNDS | VEGFA, FLT4, KDR | NPC1 3747/4885TDP1 4403/4885MAPT 3908/4885 |
| US-20080152660-A1 | Anti-Angiogenic Compounds | VEGFA, FLT4, KDR | NPC1 3747/4885TDP1 4403/4885MAPT 3908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.