Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429975 | 0.76 | CTSD (0.32) | REN | |
| SCHEMBL4429973 | 0.76 | CTSD (0.32) | REN | |
| SCHEMBL4429976 | 0.76 | CTSD (0.32) | REN | |
| SCHEMBL1567591 | 0.76 | CNR1 (0.33) | GCKCTSSCNR1CNR2USP30 | |
| SCHEMBL2028293 | 0.76 | CNR1 (0.37) | GCKCTSSCNR1CNR2USP30 | |
| SCHEMBL1867802 | 0.74 | CTSS (0.31) | CTSS | |
| SCHEMBL972231 | 0.71 | — | — | |
| SCHEMBL972386 | 0.71 | REN (0.40) | RENCTSS | |
| SCHEMBL970651 | 0.71 | REN (0.40) | RENCTSS | |
| SCHEMBL969489 | 0.71 | REN (0.40) | RENCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872028-B2 | Diaminopropanol renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | disclosed |