Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972386 | 1.00 | REN (0.40) | RENLTA4HCTSSCTSKGRN | |
| SCHEMBL969489 | 0.83 | REN (0.40) | RENCTSSCTSKCPB2 | |
| SCHEMBL9226154 | 0.82 | REN (0.45) | RENLTA4HCTSKCPB2 | |
| SCHEMBL7280734 | 0.82 | REN (0.45) | RENLTA4HCTSKCPB2 | |
| SCHEMBL9226159 | 0.82 | REN (0.45) | RENLTA4HCTSKCPB2 | |
| SCHEMBL1862727 | 0.77 | LTA4H (0.43) | RENLTA4HCTSKGRNSORT1 | |
| SCHEMBL7323217 | 0.77 | REN (0.41) | RENLTA4HCTSK | |
| SCHEMBL7323220 | 0.77 | REN (0.41) | RENLTA4HCTSK | |
| SCHEMBL1859134 | 0.77 | CTSK (0.39) | RENLTA4HCTSSCTSKCPB2 | |
| SCHEMBL7268749 | 0.77 | CTSK (0.39) | RENLTA4HCTSSCTSKCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872028-B2 | Diaminopropanol renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | disclosed |