Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.62 |
| ▸ | HNF4A | P41235 | 2/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9730413 | 0.82 | HNF4A (0.51) | ACMSDHNF4ACYP1A2SMN1; SMN2ALOX5 | |
| SCHEMBL27757652 | 0.80 | ACMSD (0.66) | ACMSDHNF4ADHFRMCL1SMN1; SMN2 | |
| SCHEMBL4948042 | 0.79 | HDAC1 (0.52) | ACMSDHNF4AFFAR1DHFRMCL1 | |
| Biphenyl SCHEMBL27929406 | 0.78 | FFAR1 (0.61) | FFAR1LMNACYP1A2RAB9ASMN1; SMN2 | |
| Glutarate SCHEMBL250428 | 0.78 | FFAR1 (0.61) | FFAR1LMNACYP1A2RAB9ASMN1; SMN2 | |
| SCHEMBL9077857 | 0.78 | HDAC3 (0.58) | LMNARAB9ASMN1; SMN2HTTHDAC1 | |
| SCHEMBL9245988 | 0.77 | ACMSD (0.78) | ACMSDHNF4ADHFRMCL1LMNA | |
| SCHEMBL29810721 | 0.77 | ACMSD (1.00) | ACMSDHNF4ADHFRMCL1SMN1; SMN2 | |
| SCHEMBL2536183 | 0.77 | ACMSD (1.00) | ACMSDHNF4ADHFRMCL1SMN1; SMN2 | |
| SCHEMBL29164312 | 0.76 | HDAC3 (0.61) | LMNARAB9ASMN1; SMN2HTTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5141951-A | Treatment or prophylaxis of asthma, treatment of inflammation or psoriasis | SANDOZ LTD. (CH) | 1992-08-25 | — | — | US | disclosed |
| EP-0446180-A1 | 5-Phenyl-1H-pyrazol-4-propionic acid derivatives, their preparation and their use | SANDOZ LTD. (CH) | 1991-09-11 | — | — | EP | disclosed |