Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.51 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25369718 | 0.83 | MCL1 (0.53) | HNF4AACMSDALDH1A1DHODHSMN1; SMN2 | |
| SCHEMBL14925380 | 0.82 | HTT (0.68) | HTTHPGDALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL9730381 | 0.82 | ACMSD (0.62) | HNF4AACMSDHTTALOX5CYP1A2 | |
| SCHEMBL9345558 | 0.82 | CYP4F2 (0.50) | CYP4F2CYP4A11ALDH1A1ALOX5CYP1A2 | |
| SCHEMBL9730324 | 0.81 | MCL1 (0.53) | MMEL1ALOX5CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL3303798 | 0.80 | CA12 (0.64) | HNF4AACMSDHPGDALDH1A1GAA | |
| SCHEMBL29178208 | 0.79 | CYP4F2 (0.51) | HTTCYP4F2CYP4A11ALDH1A1CYP1A2 | |
| SCHEMBL8567923 | 0.78 | CYP4F2 (0.58) | CYP4F2CYP4A11ALDH1A1ALOX5CYP1A2 | |
| SCHEMBL27757652 | 0.78 | ACMSD (0.66) | HNF4AACMSDHPGDALDH1A1ALOX5 | |
| SCHEMBL3382930 | 0.78 | L3MBTL1 (0.59) | HPGDCYP4F2CYP4A11ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5141951-A | Treatment or prophylaxis of asthma, treatment of inflammation or psoriasis | SANDOZ LTD. (CH) | 1992-08-25 | — | — | US | disclosed |
| EP-0446180-A1 | 5-Phenyl-1H-pyrazol-4-propionic acid derivatives, their preparation and their use | SANDOZ LTD. (CH) | 1991-09-11 | — | — | EP | disclosed |