Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739402 | 0.90 | GRIN1 (0.81) | GRIN1HDAC1FBP1GPR17DRD2 | |
| SCHEMBL9731518 | 0.84 | GRIN1 (0.79) | GRIN1HDAC1FBP1GPR17DRD2 | |
| SCHEMBL9732077 | 0.80 | GRIN1 (1.00) | GRIN1HDAC1FBP1GPR17MAPK1 | |
| SCHEMBL9732770 | 0.72 | GRIN1 (0.69) | GRIN1FBP1GPR17HPGDMAPK1 | |
| SCHEMBL9731682 | 0.71 | GRIN1 (0.54) | GRIN1FBP1GPR17 | |
| SCHEMBL9730824 | 0.71 | GRIN1 (0.64) | GRIN1FBP1GPR17KDM4EALDH1A1 | |
| SCHEMBL8416073 | 0.67 | DRD2 (0.55) | HDAC1DRD2DRD3KCNH2KDM4E | |
| SCHEMBL9731504 | 0.67 | GRIN1 (0.53) | GRIN1FBP1GPR17MAPT | |
| SCHEMBL9731643 | 0.66 | HDAC1 (0.45) | GRIN1HDAC1DRD2DRD3KCNH2 | |
| SCHEMBL499309 | 0.64 | GRIN1 (0.59) | GRIN1GPR17MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | claimed |
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |