Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732813 | 0.91 | HRH1 (0.48) | TBXAS1ALDH1A1L3MBTL1TDP1LMNA | |
| SCHEMBL9732403 | 0.86 | TBXAS1 (0.48) | TBXAS1ALDH1A1L3MBTL1TDP1LMNA | |
| SCHEMBL9732456 | 0.84 | TBXAS1 (0.47) | TBXAS1ALDH1A1L3MBTL1TDP1CHRNA7 | |
| SCHEMBL9732300 | 0.80 | PKM (0.41) | TBXAS1PTAFR | |
| SCHEMBL9732435 | 0.80 | TBXAS1 (0.79) | TBXAS1 | |
| SCHEMBL11427621 | 0.77 | L3MBTL1 (0.49) | TBXAS1ALDH1A1L3MBTL1TDP1LMNA | |
| SCHEMBL9709504 | 0.76 | TBXAS1 (0.43) | TBXAS1ALDH1A1L3MBTL1TDP1CHRNA7 | |
| SCHEMBL10713540 | 0.75 | TDP1 (0.53) | TBXAS1L3MBTL1TDP1CHRNA7PTAFR | |
| SCHEMBL10622938 | 0.75 | TBXAS1 (0.57) | TBXAS1ALDH1A1L3MBTL1TDP1CHRNA7 | |
| SCHEMBL11427624 | 0.74 | TDP1 (0.51) | TBXAS1ALDH1A1L3MBTL1TDP1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |