Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010805 | 0.92 | TSHR (0.50) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL11517368 | 0.90 | TSHR (0.65) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL30839728 | 0.90 | TSHR (0.65) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL398356 | 0.85 | ALDH1A1 (0.54) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL440944 | 0.84 | TP53 (0.61) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL29364307 | 0.84 | TP53 (0.61) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL2495842 | 0.79 | AHR (0.52) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL14907071 | 0.78 | TSHR (0.56) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL30839733 | 0.77 | TSHR (0.48) | TSHRCYP3A4TP53ALDH1A1ALOX15 | |
| SCHEMBL27185998 | 0.77 | TSHR (0.48) | TSHRCYP3A4TP53ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145790-A | Immunoassay, fluorescein derivative | ABBOTT LABORATORIES (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0455058-A2 | Reagents and method for detecting polychlorinated biphenyls | ABBOTT LABORATORIES (US) | 1991-11-06 | — | — | EP | disclosed |