Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732124 | 0.85 | TSHR (0.58) | ALDH1A1TSHRTP53HTR2BPDE4D | |
| SCHEMBL397076 | 0.83 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TSHRTP53CYP3A4 | |
| SCHEMBL29416774 | 0.82 | PTPN1 (0.56) | ALDH1A1TSHRTP53HTR2BPDE4D | |
| SCHEMBL29983105 | 0.82 | PTPN1 (0.56) | ALDH1A1TSHRTP53HTR2BPDE4D | |
| SCHEMBL381603 | 0.82 | PTPN1 (0.56) | ALDH1A1TSHRTP53HTR2BPDE4D | |
| SCHEMBL642233 | 0.80 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1TSHRTP53CYP3A4 | |
| SCHEMBL3279467 | 0.80 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1TSHRTP53CYP3A4 | |
| SCHEMBL17785867 | 0.80 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1TSHRTP53CYP3A4 | |
| SCHEMBL29364307 | 0.79 | TP53 (0.61) | ALDH1A1TSHRTP53HTR2BPDE4D | |
| SCHEMBL440944 | 0.79 | TP53 (0.61) | ALDH1A1TSHRTP53HTR2BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090011935-A1 | Method of Inducing Tolerance of Plants Against Bacterioses | BASF SE (DE) | 2009-01-08 | — | — | US | claimed |
| EP-1996018-A2 | METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES | BASF SE (DE) | 2008-12-03 | — | — | EP | claimed |
| WO-2007104658-A2 | METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES | BASF SE (DE) | 2007-09-20 | — | — | WO | claimed |
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-03 | — | — | US | disclosed |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-11-05 | — | — | US | disclosed |
| US-6627643-B2 | Sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula I' are useful for the prevention and treatment of myocardial ischemic injury. Myocardial ischemic injury can occur in out-patient in perioperative settings and can lead to sudden | PFIZER INC. | 2003-09-30 | — | — | US | disclosed |
| EP-1337508-A1 | PREPARATION OF SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITORS | Pfizer Products Inc. (US) | 2003-08-27 | — | — | EP | disclosed |
| WO-2003051845-A1 | METHODS FOR PREPARING SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-06-26 | — | — | WO | disclosed |
| US-20030119873-A1 | METHODS FOR PREPARING SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITORS | PFIZER INC. | 2003-06-26 | — | — | US | disclosed |
| US-20020082274-A1 | Preparation of sodium-hydrogen exchanger type-1 inhibitors | LAMBERT JOHN F (US) | 2002-06-27 | — | — | US | disclosed |
| WO-2002044133-A1 | PREPARATION OF SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-06-06 | — | — | WO | disclosed |
| EP-0215312-B1 | METHOD FOR PRODUCING OF POLYARYLENE SULFIDES | IDEMITSU PETROCHEMICAL CO. LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| EP-0215312-A1 | Method for producing of polyarylene sulfides | IDEMITSU PETROCHEMICAL CO. LTD. (JP) | 1987-03-25 | — | — | EP | disclosed |
| EP-0213080-A2 | Hydrogenated pyridine derivatives | CIBA-GEIGY AG (CH) | 1987-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | ALDH1A1 2165/4885L3MBTL1 3552/4885TSHR 2753/4885 |
| US-20090011935-A1 | Method of Inducing Tolerance of Plants Against Bacterioses | BROX, CAT, SLC11A2 | ALDH1A1 2207/4885L3MBTL1 417/4885TSHR 3387/4885 |
| US-20030119873-A1 | METHODS FOR PREPARING SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITORS | NHERF1, SLC9A1, SLC9A2 | ALDH1A1 637/4885L3MBTL1 4798/4885TSHR 2288/4885 |
| US-20020082274-A1 | Preparation of sodium-hydrogen exchanger type-1 inhibitors | SLC9A1, NHERF1, SLC9A5 | ALDH1A1 531/4885L3MBTL1 4619/4885TSHR 1725/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | ALDH1A1 2165/4885L3MBTL1 3552/4885TSHR 2753/4885 |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | ALDH1A1 2165/4885L3MBTL1 3552/4885TSHR 2753/4885 |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | ALDH1A1 2165/4885L3MBTL1 3552/4885TSHR 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.