Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733074 | 1.00 | MAPK1 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2579539 | 0.88 | LMNA (0.72) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11387099 | 0.83 | TDP1 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9646805 | 0.83 | TDP1 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11387103 | 0.83 | TDP1 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9646816 | 0.83 | TDP1 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5961390 | 0.83 | SIGMAR1 (0.75) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7261524 | 0.83 | LMNA (0.62) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL28015193 | 0.83 | LMNA (0.62) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11403894 | 0.81 | HRH3 (0.61) | MAPK1TDP1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164391-A | Treatment of diabetes and circulatory disorders, aldose reductase inhibitor | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| EP-0418834-A1 | Hydantoin derivatives for treating complications of diabetes and circulatory diseases | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |