Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261524 | 1.00 | LMNA (0.62) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| Alcohol SCHEMBL28193502 | 0.92 | ALDH1A1 (0.56) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| Alcohol SCHEMBL28193504 | 0.92 | ALDH1A1 (0.56) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL2579539 | 0.91 | LMNA (0.72) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL613704 | 0.83 | LTA4H (0.77) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL11036914 | 0.83 | LTA4H (0.77) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL9733074 | 0.83 | MAPK1 (0.61) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL9733076 | 0.83 | MAPK1 (0.61) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL5961390 | 0.82 | SIGMAR1 (0.75) | LMNAMAPK1HIF1ACYP2D6CYP3A4 | |
| SCHEMBL27580427 | 0.82 | ALDH1A1 (0.63) | LMNAMAPK1HIF1ACYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107840854-A | Use and preparation method of 3- (4-cinnamyl-1-piperazinyl) amino derivative of 3-formylrifamycin SV | 阿迪帕姆单人股份公司 | 2018-03-27 | — | — | CN | claimed |
| CN-104736152-A | Pharmaceutical formulations comprising 3- (4-cinnamyl-1-piperazinyl) amino derivatives of 3-formylrifamycin SV and 3-formylrifamycin S and processes for their preparation | ADIPHARM EAD | 2015-06-24 | — | — | CN | claimed |
| CN-104736152-A | Pharmaceutical formulations comprising 3- (4-cinnamyl-1-piperazinyl) amino derivatives of 3-formylrifamycin SV and 3-formylrifamycin S and processes for their preparation | ADIPHARM EAD | 2015-06-24 | — | — | CN | disclosed |