Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28239560 | 0.90 | POLB (0.60) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL797463 | 0.86 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL9733878 | 0.85 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL8685723 | 0.85 | SLC2A1 (0.55) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL28900440 | 0.84 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL9584018 | 0.84 | PLA2G2A (0.61) | ALDH1A1LMNABCHE | |
| SCHEMBL13131367 | 0.82 | MAPT (0.57) | ALDH1A1LMNAKMT2APOLBABCC2 | |
| SCHEMBL18509023 | 0.82 | MAPT (0.56) | LMNAKMT2AMEN1POLBABCC2 | |
| SCHEMBL28530692 | 0.81 | ABCC2 (0.60) | ALDH1A1SMN1; SMN2LMNATDP1KMT2A | |
| SCHEMBL28477087 | 0.81 | BCHE (0.55) | ALDH1A1SMN1; SMN2LMNATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108358923-B | Sophoridine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108047226-B | Matrine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108358923-A | Sophoridine pyrroles, indole derivatives and the preparation method and application thereof | 广西大学 | 2018-08-03 | — | — | CN | claimed |
| WO-1992007829-A1 | INDOLE-3-METHANAMINES USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |