Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736703 | 1.00 | ALDH1A1 (0.55) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9737324 | 1.00 | ALDH1A1 (0.55) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9732991 | 0.99 | ALDH1A1 (0.54) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9737655 | 0.82 | KCNH2 (0.59) | ALDH1A1GAAKDM4ELMNAALOX5 | |
| SCHEMBL9732366 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9732974 | 0.80 | PKM (0.53) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9737861 | 0.80 | KCNH2 (0.54) | MAPK1KCNH2 | |
| SCHEMBL9736710 | 0.80 | KCNH2 (0.54) | MAPK1KCNH2 | |
| SCHEMBL9732998 | 0.80 | KCNH2 (0.54) | MAPK1KCNH2 | |
| SCHEMBL9738738 | 0.80 | KCNH2 (0.50) | ALDH1A1GAAMAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | claimed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | claimed |
| US-5104892-A | N-heteroalkyl substitutes 1-aryloxy-2-propanolamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |