Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.44 |
| ▸ | WNT3A | P56704 | 5/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733448 | 0.90 | ALB (0.58) | ALBHPGDCTNNB1WNT3AP2RX1 | |
| SCHEMBL7244500 | 0.83 | CTNNB1 (0.60) | NR4A2ALDH1A1KMT2ACYP1A2CTNNB1 | |
| SCHEMBL30758347 | 0.83 | CTNNB1 (0.60) | NR4A2ALDH1A1KMT2ACYP1A2CTNNB1 | |
| SCHEMBL1260174 | 0.82 | ALB (0.56) | ALBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11635520 | 0.81 | ALDH1A1 (0.51) | NR4A2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL14100100 | 0.79 | MMP2 (0.61) | NR4A2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL11701099 | 0.79 | NR4A2 (0.46) | NR4A2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL4598039 | 0.78 | ALB (0.60) | ALBALDH1A1KMT2AHSD17B10P2RX1 | |
| SCHEMBL2088179 | 0.77 | CES2 (0.52) | NR4A2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL29499773 | 0.77 | ALB (1.00) | ALBALDH1A1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | disclosed |
| EP-0156233-A2 | Use of leukotriene antagonists for producing cytoprotective pharmaceutical compositions and process for producing cytoprotective pharmaceutical compositions | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0104885-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-04 | — | — | EP | disclosed |