Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.84 |
| ▸ | DRD3 | P35462 | 4/20 | 0.84 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31232750 | 1.00 | DRD2 (0.84) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL9249351 | 0.92 | DRD2 (0.73) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL9257199 | 0.92 | DRD3 (0.86) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL9256633 | 0.92 | DRD2 (1.00) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL7976323 | 0.92 | DRD2 (0.95) | DRD2DRD3GAAALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL10826808 | 0.90 | DRD2 (0.92) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL9250065 | 0.89 | DRD2 (0.68) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL9251119 | 0.89 | DRD2 (0.68) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL6166099 | 0.88 | DRD3 (0.79) | DRD2DRD3GAAALDH1A1POLB | |
| SCHEMBL10763449 | 0.87 | DRD2 (0.95) | DRD2DRD3GAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164391-A | Treatment of diabetes and circulatory disorders, aldose reductase inhibitor | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| EP-0418834-A1 | Hydantoin derivatives for treating complications of diabetes and circulatory diseases | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |