Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.79 |
| ▸ | DRD2 | P14416 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | HRH2 | P25021 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16757317 | 0.93 | DRD3 (0.81) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL7976323 | 0.88 | DRD2 (0.95) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL9256633 | 0.88 | DRD2 (1.00) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL9733689 | 0.88 | DRD2 (0.84) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL31232750 | 0.88 | DRD2 (0.84) | DRD3DRD2ALDH1A1GAAPOLB | |
| Hydrochloric Acid SCHEMBL10826808 | 0.87 | DRD2 (0.92) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL10763449 | 0.84 | DRD2 (0.95) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL9249351 | 0.81 | DRD2 (0.73) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL9257199 | 0.81 | DRD3 (0.86) | DRD3DRD2ALDH1A1GAAPOLB | |
| SCHEMBL1463080 | 0.81 | TERT (0.55) | DRD3DRD2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060163-B1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE CO CHEM PHARM FAB (DE) | 2005-10-12 | — | — | EP | disclosed |
| US-6903118-B1 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides | KLINGE PHARMA GMBH (DE) | 2005-06-07 | — | — | US | disclosed |
| EP-1060163-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | Klinge Pharma GmbH (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999031063-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |