Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732938 | 0.84 | MAPT (0.78) | ALDH1A1MAPTNPC1GAAHTT | |
| SCHEMBL6247679 | 0.74 | MAPT (0.52) | ALDH1A1MAPTHTTLMNANPSR1 | |
| SCHEMBL31701605 | 0.70 | MAPT (0.66) | ALDH1A1MAPTLMNANPSR1POLB | |
| SCHEMBL8289567 | 0.70 | TP53 (0.72) | ALDH1A1MAPTLMNANPSR1POLB | |
| SCHEMBL9733822 | 0.69 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNANPSR1POLB | |
| SCHEMBL1272337 | 0.69 | KMT2A (0.70) | ALDH1A1NPC1GAAHTTLMNA | |
| SCHEMBL11344627 | 0.69 | ALDH1A1 (1.00) | ALDH1A1MAPTGAALMNANPSR1 | |
| SCHEMBL7933617 | 0.68 | ALDH1A1 (0.72) | ALDH1A1MAPTLMNANPSR1POLB | |
| SCHEMBL8689607 | 0.68 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTLMNANPSR1 | |
| SCHEMBL6406681 | 0.68 | KDM4E (0.72) | ALDH1A1HTTLMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124331-A | Anticancer agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| EP-0364598-A1 | 3,4-dihydrothieno ¬2,3-d pyrimidine compounds and pharmaceutical application thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-04-25 | — | — | EP | disclosed |