Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | GLA | P06280 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 6/20 | 0.42 |
| ▸ | RECQL | P46063 | 5/20 | 0.42 |
| ▸ | BLM | P54132 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734077 | 0.79 | GAA (0.41) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL9733787 | 0.77 | GAA (0.42) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL9735204 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL9733848 | 0.75 | HPGD (0.48) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL9734929 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL9735881 | 0.73 | KDM4E (0.47) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL9734834 | 0.70 | MAPT (0.48) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL3378921 | 0.69 | CFB (0.47) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL15189501 | 0.68 | MCL1 (0.48) | KDM4EALDH1A1KMT2AGLAGAA | |
| SCHEMBL2047102 | 0.68 | PGK1 (0.39) | KDM4EALDH1A1KMT2AGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106975-A | Hexahydropyrimidine derivatives | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0434185-A2 | Hexahydropyrimidine derivatives | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-06-26 | — | — | EP | disclosed |