Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 2/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12851348 | 0.88 | TP53 (0.67) | TP53SMN1; SMN2MAPK8NPC1RAB9A | |
| SCHEMBL2391690 | 0.84 | LMNA (0.49) | TP53SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL13329793 | 0.82 | GPR119 (0.42) | TP53SMN1; SMN2ANO1 | |
| SCHEMBL8979538 | 0.81 | TP53 (0.51) | TP53SMN1; SMN2GLSDNMT3BNPC1 | |
| SCHEMBL25913581 | 0.80 | P2RX7 (0.41) | TP53SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7023940 | 0.80 | MAPK8 (0.53) | SMN1; SMN2MAPK8GLSDNMT3BNPC1 | |
| SCHEMBL9890781 | 0.80 | TP53 (0.42) | TP53SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL21776096 | 0.78 | ALDH1A1 (0.56) | SMN1; SMN2MAPK8GLSNPC1RAB9A | |
| SCHEMBL8572763 | 0.78 | P2RX7 (0.41) | TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27036782 | 0.78 | KMT2A (0.44) | TP53SMN1; SMN2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098922-A | Anticonvulsants | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | disclosed |
| US-5045556-A | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |