Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 5/20 | 0.37 |
| ▸ | CDC25B | P30305 | 5/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736128 | 0.83 | CYP3A4 (0.41) | CYP3A4APP | |
| SCHEMBL9669974 | 0.80 | NAAA (0.40) | CYP3A4APPFAAH | |
| SCHEMBL8985077 | 0.76 | NAAA (0.43) | FAAHTRPA1 | |
| SCHEMBL9671073 | 0.76 | NAAA (0.43) | FAAHTRPA1 | |
| SCHEMBL7296014 | 0.75 | PDCD4 (0.47) | CDC25ACDC25B | |
| SCHEMBL4575395 | 0.67 | RIPK1 (0.52) | CYP3A4GRIK1HDAC3MAPK1ADRA1A | |
| SCHEMBL5610385 | 0.67 | HDAC3 (0.52) | GRIK1TRPA1HDAC3MAPK1ADRA1A | |
| SCHEMBL5833581 | 0.66 | TRPA1 (0.56) | GRIK1TRPA1HDAC3MAPK1ADRA1A | |
| SCHEMBL8849468 | 0.66 | HDAC3 (0.50) | GRIK1TRPA1HDAC3MAPK1ADRA1A | |
| SCHEMBL4496886 | 0.66 | CYP3A4 (0.43) | CYP3A4HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0295056-A1 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1988-12-14 | — | — | EP | disclosed |