Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124228 | 0.86 | — | — | |
| SCHEMBL1033158 | 0.68 | — | — | |
| SCHEMBL13351590 | 0.66 | HASPIN (0.30) | — | |
| SCHEMBL27601159 | 0.65 | — | — | |
| SCHEMBL21626846 | 0.63 | TET2 (0.31) | — | |
| SCHEMBL10137834 | 0.62 | CDK1 (0.34) | — | |
| SCHEMBL12870924 | 0.62 | KMT2A (0.37) | ALB | |
| SCHEMBL8845705 | 0.61 | PNP (0.44) | — | |
| Tromethamine SCHEMBL342628 | 0.59 | MEN1 (0.71) | — | |
| Tromethamine SCHEMBL8587575 | 0.57 | LMNA (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118820-A | Carbohydrate is chemical intermediate for nucleoside | ELI LILLY AND COMPANY (US) | 1992-06-02 | — | — | US | disclosed |
| US-5015743-A | 2-Deoxy-2,2-difluororibose | ELI LILLY AND COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| US-4808614-A | Difluoro antivirals and intermediate therefor | ELI LILLY AND COMPANY (US) | 1989-02-28 | — | — | US | disclosed |
| US-4692434-A | NUCLEOSIDES | ELI LILLY AND COMPANY (US) | 1987-09-08 | — | — | US | disclosed |