Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737137 | 0.83 | HTR2A (0.38) | HTR2AHTR2C | |
| SCHEMBL21028020 | 0.69 | HTR2A (0.38) | NOTUMHTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL9656458 | 0.68 | ALOX5 (0.40) | NOTUM | |
| SCHEMBL30684094 | 0.67 | CYP1A2 (0.40) | NOTUMOPRM1OPRD1OPRK1TSHR | |
| SCHEMBL233436 | 0.66 | HTR2A (0.47) | NOTUMHTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL18229909 | 0.65 | NOTUM (0.46) | NOTUMHTR2AHTR2CTSHRALDH1A1 | |
| SCHEMBL21028027 | 0.65 | KMT2A (0.37) | NOTUMTSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL21028082 | 0.64 | NR1H2 (0.35) | NOTUM | |
| SCHEMBL21028021 | 0.63 | NOTUM (0.35) | NOTUMHTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL231854 | 0.62 | HTR2A (0.51) | NOTUMHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |