Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736388 | 0.86 | CYSLTR1 (0.48) | PDE10AHTR5A | |
| SCHEMBL9736462 | 0.83 | KCNH2 (0.58) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL9733158 | 0.81 | KCNH2 (0.49) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL9737271 | 0.79 | MAPT (0.45) | MAPTALDH1A1KDM4EKMT2AAPP | |
| SCHEMBL7234281 | 0.76 | TSHR (0.64) | NPC1RAB9AKMT2ATSHRMAOB | |
| SCHEMBL16846177 | 0.76 | PDE10A (0.53) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL9736899 | 0.74 | MAPT (0.43) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL23423707 | 0.72 | PDE10A (0.56) | MAPTKDM4ENPC1PDE10AKMT2A | |
| SCHEMBL12092562 | 0.70 | PDE10A (0.62) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL9737655 | 0.70 | KCNH2 (0.59) | ALDH1A1KDM4EPDE10ALSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |