Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | NCF1 | P14598 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736388 | 0.88 | CYSLTR1 (0.48) | GPBAR1CYSLTR2CYSLTR1 | |
| SCHEMBL9678053 | 0.79 | LMNA (0.44) | MAPTKDM4ELMNAPOLBCASP6 | |
| SCHEMBL9736902 | 0.79 | MAPT (0.45) | MAPTKDM4EALDH1A1KMT2AAPP | |
| SCHEMBL9737428 | 0.78 | KCNH2 (0.59) | MAPTLMNAPOLBKCNH2KMT2A | |
| SCHEMBL5765471 | 0.76 | KDM4E (0.53) | MAPTKDM4ELMNAPOLBCASP6 | |
| SCHEMBL9736383 | 0.76 | KCNH2 (0.50) | LMNAKCNH2HRH3 | |
| SCHEMBL7234281 | 0.72 | TSHR (0.64) | LMNAKMT2A | |
| SCHEMBL2927123 | 0.71 | LMNA (0.50) | MAPTKDM4ELMNAPOLBCASP6 | |
| SCHEMBL9737655 | 0.71 | KCNH2 (0.59) | KDM4ELMNAKCNH2ALDH1A1GPBAR1 | |
| SCHEMBL188971 | 0.70 | KDM4E (0.69) | KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |