Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736899 | 0.85 | MAPT (0.43) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL9739211 | 0.82 | DRD2 (0.56) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL1694951 | 0.80 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10614795 | 0.78 | HDAC1 (0.48) | CYSLTR1CYSLTR2 | |
| SCHEMBL28332341 | 0.78 | HDAC1 (0.45) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL11935004 | 0.77 | MC4R (0.48) | CYSLTR1CYSLTR2 | |
| SCHEMBL4725706 | 0.76 | MC4R (0.51) | CYSLTR1CYSLTR2 | |
| SCHEMBL30388584 | 0.76 | KDM1A (0.50) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL9736388 | 0.75 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10616742 | 0.74 | KDM1A (0.49) | CYSLTR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |