Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739881 | 0.87 | SCN1A (0.40) | CYP2D6CASRMETAP2METAP1AURKA | |
| SCHEMBL9737111 | 0.87 | SCN1A (0.42) | CYP2D6CASRMETAP2METAP1AURKA | |
| SCHEMBL9738323 | 0.83 | KDM4E (0.56) | CYP2D6CASRMETAP2METAP1AURKA | |
| SCHEMBL9737832 | 0.82 | TPH1 (0.41) | TSHRKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL9736997 | 0.76 | CA2 (0.44) | TSHRKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL11787401 | 0.70 | CA2 (0.52) | TSHRKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL9736980 | 0.70 | CA2 (0.37) | TSHRKDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL30944279 | 0.70 | PTGER4 (0.55) | AURKARPS6KB1AURKBKDM4EALDH1A1 | |
| SCHEMBL28519320 | 0.70 | PTGER4 (0.55) | AURKARPS6KB1AURKBKDM4EALDH1A1 | |
| SCHEMBL28519323 | 0.70 | PTGER4 (0.55) | AURKARPS6KB1AURKBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145867-A | NAPHTHYLALKYLAMINO-SUBSTITUTED SULFAMOYLBENZOIC ACID DERIVATIVES, AND THE USE THEREOF AS MEDICINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |