Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736989 | 0.87 | CYP2D6 (0.40) | CYP2D6CASRMETAP2METAP1AURKA | |
| SCHEMBL9738323 | 0.84 | KDM4E (0.56) | SCN1ASCN5ASCN8ACYP2D6CASR | |
| SCHEMBL9738556 | 0.82 | SCN1A (0.41) | SCN1ASCN5ASCN8AMEN1KMT2A | |
| SCHEMBL9739881 | 0.82 | SCN1A (0.40) | SCN1ASCN5ASCN8ACYP2D6CASR | |
| SCHEMBL9737123 | 0.75 | CA2 (0.45) | MEN1KMT2ACA1CA2 | |
| SCHEMBL573694 | 0.71 | PKM (0.44) | CYP2D6CA1CA2 | |
| SCHEMBL30944279 | 0.71 | PTGER4 (0.55) | MEN1KMT2AAURKARPS6KB1AURKB | |
| SCHEMBL28519320 | 0.71 | PTGER4 (0.55) | MEN1KMT2AAURKARPS6KB1AURKB | |
| SCHEMBL28519323 | 0.71 | PTGER4 (0.55) | MEN1KMT2AAURKARPS6KB1AURKB | |
| SCHEMBL9737103 | 0.70 | CA2 (0.39) | MEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145867-A | NAPHTHYLALKYLAMINO-SUBSTITUTED SULFAMOYLBENZOIC ACID DERIVATIVES, AND THE USE THEREOF AS MEDICINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |