Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.46 |
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 5/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737165 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1MAPK1NR3C1 | |
| SCHEMBL9739294 | 0.88 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1MAPK1NR3C1 | |
| SCHEMBL9739289 | 0.88 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1MAPK1NR3C1 | |
| SCHEMBL11688880 | 0.84 | LMNA (0.61) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL11688872 | 0.84 | LMNA (0.61) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL11688884 | 0.84 | LMNA (0.61) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL19762243 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL11523625 | 0.83 | NR3C1 (0.64) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL9521229 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2ALDH1A1NR3C1PGR | |
| SCHEMBL11523629 | 0.83 | NR3C1 (0.64) | LMNASMN1; SMN2ALDH1A1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278319-B1 | 9,11-EPOXY-21-HYDROXYPREGNANE DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-10-07 | — | — | EP | claimed |
| US-4929395-A | 16α-methylation process | THE UPJOHN COMPANY (US) | 1990-05-29 | — | — | US | claimed |
| EP-0278319-A1 | 9,11-Epoxy-21-hydroxypregnane derivatives | THE UPJOHN COMPANY (US) | 1988-08-17 | — | — | EP | claimed |
| EP-0165037-A2 | 16 alpha-methyl steroids and their preparation | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | claimed |
| EP-0278319-B1 | 9,11-EPOXY-21-HYDROXYPREGNANE DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-10-07 | — | — | EP | disclosed |
| US-4990612-A | 16α-methylation process | THE UPJOHN COMPANY (US) | 1991-02-05 | — | — | US | disclosed |
| EP-0165037-B1 | 16 ALPHA-METHYL STEROIDS AND THEIR PREPARATION | THE UPJOHN COMPANY (US) | 1990-09-19 | — | — | EP | disclosed |
| US-4929395-A | 16α-methylation process | THE UPJOHN COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4891426-A | EPOXIDATION WITH PERACID | THE UPJOHN COMPANY (US) | 1990-01-02 | — | — | US | disclosed |
| US-4704455-A | 16α-methylatedΔ17(20)-corticoids | THE UPJOHN COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0165037-A2 | 16 alpha-methyl steroids and their preparation | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |