Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670231 | 0.81 | RAPGEF4 (0.60) | RAPGEF4HTR6CDC7CDK2SLC22A12 | |
| SCHEMBL29723138 | 0.76 | HTR6 (0.56) | RAPGEF4HTR6HTTSMN1; SMN2TSHR | |
| SCHEMBL9237396 | 0.76 | HTR6 (0.56) | RAPGEF4HTR6HTTSMN1; SMN2TSHR | |
| SCHEMBL25371051 | 0.74 | CDC7 (0.41) | RAPGEF4HTR6CDC7CDK2SMN1; SMN2 | |
| SCHEMBL31609647 | 0.74 | CDC7 (0.41) | RAPGEF4HTR6CDC7CDK2SMN1; SMN2 | |
| SCHEMBL9941023 | 0.74 | RAPGEF4 (0.71) | RAPGEF4HTR6HTTTSHRHDAC3 | |
| SCHEMBL2672867 | 0.73 | HTR6 (0.66) | RAPGEF4HTR6HTTMETTSHR | |
| SCHEMBL15175729 | 0.72 | RAPGEF4 (1.00) | RAPGEF4HTR6HTTMETSMN1; SMN2 | |
| SCHEMBL29723148 | 0.71 | FABP4 (0.50) | HTR6HTTSMN1; SMN2KDM4EGAA | |
| SCHEMBL16923788 | 0.69 | HTR6 (0.35) | RAPGEF4HTR6HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079363-A | From an alkoxypyridine and an indole derivative, antitumor and antileukemia agents | SANOFI (FR) | 1992-01-07 | — | — | US | disclosed |