Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.53 |
| ▸ | DRD2 | P14416 | 14/20 | 0.53 |
| ▸ | HTR2A | P28223 | 13/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522190 | 0.92 | HTR1A (0.53) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL9131492 | 0.85 | DRD2 (0.60) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| Water SCHEMBL9318473 | 0.84 | DRD2 (0.59) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL9133222 | 0.77 | DRD2 (0.61) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL8786866 | 0.74 | ACHE (0.50) | DRD2HTR2ASLC6A4HTR7KCNH2 | |
| SCHEMBL8506902 | 0.74 | ACHE (0.50) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL7420789 | 0.74 | KCNH2 (0.49) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL5328181 | 0.73 | DRD2 (0.75) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL8789450 | 0.73 | DRD2 (0.42) | HTR1ADRD2HTR2AHRH3SLC6A4 | |
| SCHEMBL8789335 | 0.73 | ACHE (0.47) | HTR1ADRD2HTR2ASLC6A4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992008718-A1 | 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1992-05-29 | — | — | WO | claimed |