Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012895 | 0.73 | LMNA (0.56) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL11544937 | 0.73 | LMNA (0.56) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL8945843 | 0.73 | MAPT (0.33) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL9738711 | 0.72 | LIMK1 (0.41) | KDM4EALDH1A1HPGD | |
| SCHEMBL6491041 | 0.72 | ALDH1A1 (0.38) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL27513090 | 0.71 | LMNA (0.46) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL526383 | 0.71 | MAPT (0.58) | MAPTADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL7800130 | 0.70 | ALDH1A1 (0.45) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9480308 | 0.70 | CNR2 (0.35) | MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL20710 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |