Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TDO2 | P48775 | 7/20 | 0.39 |
| ▸ | IDO1 | P14902 | 6/20 | 0.39 |
| ▸ | CDC42 | P60953 | 2/20 | 0.35 |
| ▸ | RAC1 | P63000 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164412 | 0.81 | MAPT (0.36) | MAPTACHEKDM4EALDH1A1HPGD | |
| SCHEMBL9621055 | 0.80 | MAOA (0.47) | MAPTCYP3A4ACHEKDM4EALDH1A1 | |
| SCHEMBL4465114 | 0.80 | CYP19A1 (0.41) | MAPTKDM4EALDH1A1MAPK1NQO1 | |
| SCHEMBL8556354 | 0.80 | MAPT (0.35) | MAPTCYP3A4TDO2IDO1NQO1 | |
| SCHEMBL8722679 | 0.80 | MAPT (0.35) | MAPTHPGDNQO1 | |
| SCHEMBL4326638 | 0.80 | CYP19A1 (0.41) | MAPTCYP3A4TDO2IDO1HPGD | |
| SCHEMBL8721893 | 0.77 | KMT2A (0.38) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL28902991 | 0.76 | KDM2B (0.37) | MEN1KMT2A | |
| SCHEMBL386606 | 0.76 | NQO1 (0.44) | MAPTCYP3A4ACHEKDM4EALDH1A1 | |
| SCHEMBL8716900 | 0.75 | CA9 (0.48) | MAPTCYP3A4KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |