Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703931 | 0.80 | MAPT (0.42) | TAAR1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9738560 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1MAPTTHRB | |
| SCHEMBL17684664 | 0.69 | TAAR1 (0.40) | TAAR1HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL9059555 | 0.68 | CHRNB2 (0.36) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL31075268 | 0.67 | KDM1A (0.47) | TAAR1MEN1KMT2AALDH1A1MAPT | |
| Cyanamide SCHEMBL27345527 | 0.66 | ALDH1A1 (0.52) | TAAR1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL17735939 | 0.66 | KDM1A (0.39) | TAAR1ALDH1A1MAPTTHRBHTT | |
| SCHEMBL17728209 | 0.66 | TAAR1 (0.37) | TAAR1HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL15327483 | 0.65 | TAAR1 (0.44) | TAAR1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL17684167 | 0.65 | HSD11B1 (0.39) | TAAR1HTR2AHTR2CHTR2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082842-A | Sedatives | HOFFMANN-LA ROCHE INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-4889854-A | MUSCLE RELAXANT, SEDATIVE-HYPNOTIC, ANXIOLYTIC AND-OR ANTICONVULSANT ACTIVITY | HOFFMAN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0294599-A2 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-12-14 | — | — | EP | disclosed |